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Somatic mutations in chromatin remodeler genes could modify the epigenomic landscape of CLL, but They are really unheard of In this particular malignancy compared to other lymphoid neoplasms. CHD2 is mutated in five% of CLL and 7% of MBL.seventy five The histone methyltransferase SETD2 and ARID1A are also mutated in a little proportion of clients.